It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.
What is the difference between Nicotinamide and Niacin? Stacy Wiegman, PharmD. Nicotinamide can be taken by children and adults to supplement a natural supply of vitamin B3.
What is vitamin B3 used for? Vitamin B3 -- niacin -- is helpful in reducing cholesterol and triglyceride levels and also in reduc What are the side effects of niacin? Your body can also make vitamin B3 from tryptophan , an amino acid present in most protein foods. However, the conversion of tryptophan to vitamin B3 is inefficient, as it takes 60 mg of tryptophan to make just 1 mg of vitamin B3 1.
Pellagra is rare in developed countries like North America and Europe, but the disease is still frequent in some developing countries 4. Niacinamide is a form of vitamin B3, an essential nutrient that supports many cellular processes.
Niacinamide is found primarily in animal-based products and is the preferred form of vitamin B3 for treating pellagra.
Aside from being the preferred form of niacin for treating pellagra, niacinamide has several other health benefits and uses. When applied topically or taken orally as a supplement, niacinamide has been shown to have anti-inflammatory effects on the skin 5. It has been used to treat skin conditions like acne and rosacea, a facial skin disorder characterized by redness 5 , 6.
This makes niacinamide a popular alternative to oral or topical antibiotics for treating acne or rosacea 7 , 8. Melanoma is a serious type of skin cancer that develops in the cells that produce melanin, the pigment that gives your skin its color. Exposure to ultraviolet UV radiation, either from the sun or tanning beds, damages the DNA of your cells over time and is strongly correlated with melanoma.
Owing to its role in keeping your cells healthy, oral supplements of niacinamide have been shown to enhance DNA repair in UV damaged skin in humans 9 , As such, niacinamide is a promising supplement that may protect against melanoma, especially in high-risk populations, such as those who have had previous nonmelanoma skin cancers 11 , 12 , 13 , This can cause a harmful buildup of chemicals, such as phosphate, in your blood Research suggests that niacinamide may help decrease phosphate levels in people with kidney dysfunction by blocking its absorption 16 , 17 , 18 , Phosphate levels are otherwise typically managed through diet, medications or dialysis, depending on the severity of the buildup Type 1 diabetes is a condition in which your body attacks and destroys the insulin-producing beta cells of the pancreas.
While promising, more research is needed before niacinamide supplements can be recommended as an intervention for type 1 diabetes. Niacinamide may benefit those with certain skin conditions and reduce the risk of melanoma in high-risk individuals. It may also be useful for people with chronic kidney disease and, to a lesser extent, type 1 diabetes.
Vitamin B3, in the form of nicotinic acid or niacinamide, is available as a supplement either by itself or alongside other vitamins and minerals in doses ranging from 14 to 1, mg per serving. The vitamin is also included in B-complex supplements , which contain all eight B vitamins.
Some supplements that contain vitamin B3 only list niacin, but most supplements specify the form of niacin as either nicotinic acid or niacinamide. Niacinamide may be included in pre-workout supplements , but nicotinic acid, the form that causes flushing of the skin, is preferred for the purpose of giving the consumer a sense that the pre-workout has kicked-in following the skin flushing.
Government mandates called for food groups like flour to be niacin-enriched in efforts to address the larger populace. Pellagra has become a thing of the past, but we've learned that niacin does a lot more, identified as a treatment for high cholesterol in the decades that followed. As noted in the Mayo Clinic, doctors sometimes prescribe niacin to increase high-density lipoprotein HDL cholesterol , more colloquially known as "good cholesterol.
The CDC notes rising levels of "bad cholesterol" increase the risk of plaque formation in blood vessels. Plaque build-up and inflammation can make the vessels stiffer, causing high blood pressure. Niacin helps prevent this process by regulating how the liver produces cholesterol.
When kidneys lose function, they don't get rid of enough phosphate, which then binds calcium and interferes with vital heart and muscle function. Niacin helps support cells under duress, such as kidney cells in chronic conditions. Research published in the Clinical Journal of the American Society of Nephrology shows that niacin promotes phosphate control in the kidneys. As noted by Healthline, niacin has an Achilles' heel: intense flushing. Although presumed harmless, the flushing attributes of niacin can be uncomfortable, causing redness, itchiness, and warmth of the skin.
Usually, the flushing goes away as your body gets acclimated. But much of the enthusiasm around niacin dampened after learning of this unpleasant side effect. Nicotinamide NAM , sometimes known as niacinamide, acts similarly to niacin but has a different molecular structure. This subtle difference allows nicotinamide to bypass the step that causes niacin's annoying flushing, providing the benefits of vitamin B3 without making you self-conscious. It is often presented as redness, warmth, swelling, crusting, and other symptoms of acne.
A review paper published in Dermatologic Therapy outlines how multiple studies have found nicotinamide to be an effective treatment for uncontrolled acne. While many dermatologists currently recommend nicotinamide, the data remains inconclusive, and large trials are required to assess efficacy.
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