Superovulation, also known as controlled ovarian hyperstimulation, is the process of inducing a woman to release more than one egg in a month.
It is different from ovulation induction , where the goal is to release one egg a month. Women with open fallopian tubes and whose partners have adequate sperm counts are candidates for superovulation. If a woman already ovulates and is not conceiving, REI doctors can increase her chance of getting pregnant by causing her to release more eggs via superovulation. Similarly, if a woman has been ovulating with an oral medication such as clomiphene and is not conceiving, superovuation can improve her chances of conceiving by stimulating her ovaries to release more eggs.
Women who naturally ovulate may release extra eggs when they take oral medications such as clomiphene. This is a mild form of superovulation and is generally low in cost and risk. We recommend an ultrasound around the time of ovulation to determine how many follicles are growing. If the ultrasound reveals that the woman is producing just one follicle, the dose or medication might be changed in the next cycle.
Many women undergoing superovulation will opt for gonadotropins. Gonadotropins are hormones that cause eggs to grow. These medicines are given by injection with a small needle, just beneath the skin. Many different brands are available, including Bravelle, Follistim, Gonal-F, Menopure and Repronex, but most are equally effective.
Your physician will select the dose and brand prior to your treatment. Given in high doses, gonadotropins will cause multiple eggs to grow at the same time.
Remember that if you ovulate four eggs, there is a possibility you could conceive quadruplets. Superovulation might not be successful in women over age 40 and women diagnosed with primary ovarian insufficiency also known as POI or premature ovarian failure. You might need to see a specialist with specific experience or consider using an egg donor.
In fact, IVF success rates with an egg donor are good. Ideally, your doctor won't want to put you through IVF or superovulation if they don't think it will work for you. This is why ovarian reserve testing is done. Ovarian reserve testing is intended to predict how you will respond to fertility drugs during IVF. Another test called the Clomid challenge test CCT is also used at times to predict potential superovulation success.
Be sure to talk to your doctor about whether or not they think this will be a successful route. Get diet and wellness tips to help your kids stay healthy and happy. History and challenges surrounding ovarian stimulation in the treatment of infertility. Fertil Steril. Treatment outcome of ovulation-inducing agents in patients with anovulatory infertility: A prospective, observational study.
J Pharmacol Pharmacother. Live birth rates following natural cycle IVF in women with poor ovarian response according to the Bologna criteria. Hum Reprod. Optimum oocyte retrieved and transfer strategy in young women with normal ovarian reserve undergoing a long treatment protocol: A retrospective cohort study.
J Assist Reprod Genet. Is in vitro fertilisation more effective than stimulated intrauterine insemination as a first-line therapy for subfertility? A cohort analysis.
Trends and outcomes for donor oocyte cycles in the United States, American Society for Reproductive Medicine. Typically, that is. The presence of multiple Queen Eggs could mean the release of both during ovulation—resulting in the possibility of a fraternal twin pregnancy if both are fertilized!
Multiple studies 1 , 2 , 3 have demonstrated that, likely due to anatomical differences between the right and left sides of the reproductive system, the right ovary is significantly more likely to serve as the palace for your Queen Egg. PMS, or premenstrual syndrome, refers to the collection of symptoms like headaches, cramps, mood swings, and food cravings that many women experience just before or during their period.
However, about two weeks before PMS makes its visit, some women experience different symptoms—those associated with ovulation. During each cycle, a woman typically releases an egg only after it has sufficiently matured. With more FSH, the odds of two eggs being released per cycle — one from each ovary — may increase, the researchers hypothesized.
Women with this variant may produce average levels of FSH, but have ovaries that are more sensitive to the hormone, triggering the release of two oocytes per month. Still, these two gene variations are only part of the puzzle. Together, they increase a woman's odds of having twins by only about 29 percent, suggesting that many other genes may be involved in the process, Boomsma said.
Original article on Live Science.
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